• The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq, Jul 2008]
  

SDC1 (Syndecan 1) is a Protein Coding gene. Diseases associated with SDC1 include Monoclonal Gammopathy Of Uncertain Significance and Endometritis. Among its related pathways are Chondroitin sulfate/dermatan sulfate metabolism and Defective EXT1 causes exostoses 1, TRPS2 and CHDS. Gene Ontology (GO) annotations related to this gene include obsolete protein C-terminus binding and protein binding. An important paralog of this gene is SDC3.